Estacado High School, located at 1504 E. Itasca Avenue, opened in the fall of 1967. It was named for the early South Plains community of Estacado, which was located east of Lubbock on the Lubbock-Crosby county line.

Estacado was composed primarily of Quaker settlers. These farmers traveled from Indiana and began arriving in the area in 1879. The community was credited with the first school, first church, first hotel, and first post office in the county. The name, Estacado, is derived from the Spaniards' designation of the area as the Llano Estacado, or Land of the Staked Plains.

The high school was designed for 1,600 students and total cost for the facility was $3.8 million. In addition to the traditional classrooms, the school originally contained a vocational wing with labs and shops for agriculture business, business practice, electronic trades, sheet metal and metal working trades, cabinetry and millwork trades, and automobile body works. The vocational classes were eventually relocated to the ATC facility for access by students from all LISD high school campuses. The medical magnet program was added in the early 1990s. An engineering magnet was piloted at Estacado, and the criminal justice magnet was added in 2007.  Lubbock Independent School District, Estacado High School and Texas Tech University partnered in 2016 to form Estacado Early College High School.

1967-1970:     Mr. Olan Rice

1970-1978:     Mr. E.W. "Tebo" Reed

1978-1982:     Mr. Curtis Gipson

1981-1989:     Mr. Carrol Thomas

1989-1999:     Mr. Kenneth Wallace

1999-2000:     Mr. Wendell Brown

2000-2002:     Ms. Carolyn Thompson-Conwright

2002-2007:     Mr. Paul Frazier

2007-2010:     Mr. David Vasquez

2010-2014:     Dr. Sam Ayers

2014-2016:     Mr. Jimmy Moore

2016-Present: Mrs. Angelica Wilbanks